Rune sets
Each set has six runes. Equipping more pieces of one set unlocks its bonuses at 2, 4 and 6.
Warrior
Strong Shield of the Atheron
Eye of the Storm
Weight of the Mountain
2 pieces: +100% Special Ability Damage.
4 pieces: Each Basic Attack cast reduces Earthstrike's cooldown by 0.8 seconds.
6 pieces: When a Stun you inflicted ends, the enemy is left Fractured for 8 seconds, taking +250% Critical Hit Damage from you.
Harvest Moon
2 pieces: +50% Strong Attack Damage.
4 pieces: Each enemy struck by Half Moon Slash grants a stack of Crescent Momentum for 3 seconds, up to 20 stacks. Each stack grants +1 Mana Regeneration and +1% Critical Hit Chance.
6 pieces: Half Moon Slash's blades no longer fly past. They hunt the enemies around where you aimed for 3 seconds.
Sorcerer
Infernal Covenant
Frozen Barrage
2 pieces: +65% Damage to Slowed enemies.
4 pieces: +60% Attack Speed. Ice Shards also applies Chill.
6 pieces: Ice Shards fires 4 additional projectiles. Each projectile can pierce through 1 target.
Stormcaller
Hunter
Trapper's Legacy
Deadeye's Resolve
Venomfang
2 pieces: Damage against poisoned enemies increased by 70%.
4 pieces: Applying poison reduces the target's movement speed by 25% and attack speed by 20% for 5 seconds. Reapplying poison refreshes the slow.
6 pieces: Casting Poison Shot has a 50% chance to launch an arcing venom projectile that deals 420% weapon damage as Poison in a small area and applies 2 stacks of poison to all enemies hit.
Monk
Hundred Hands
2 pieces: +100% Basic Attack Damage.
4 pieces: Each stack of Furious Fist also grants +3% Physical Damage, up to +60% at 20 stacks.
6 pieces: Your Furious Fist has a 25% chance to unleash Golden Palms for free, without knockback. These Golden Palms inflict Dazed and deal 0.5% more damage per point of current Mana.
Wheel of Nine Heavens
Serpent's Tongue
2 pieces: +50% Strong Attack Damage.
4 pieces: Piercing Lunge costs half as much Mana.
6 pieces: Piercing Lunge's airflow pierces through enemies behind the target, inflicting Vulnerable. Each cast also reduces the remaining cooldown of a random Special ability by 1 second.